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Additionally, polymorphisms in GPX1 (e.g., Pro198Leu, rs1050450) have been associated with decreased enzymatic activity and increased OS, potentially exacerbating autoimmune thyroid conditions

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Current evidence suggests potential complementary effects, particularly for polycystic ovary syndrome (PCOS) or metabolic dysfunction, though safety and timing require individualized assessment

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Maniakas A, Davies L, Zafereo ME