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During ER stress, GRP78, the primary regulator of UPR, dissociates from the ER compartment, activating the main PERK protein pathway

To selectively activate endogenous GLP-1-producing NTS neurons that project to the VTA, the retrogradely infecting virus CAV2 expressing Cre recombinase (CAV2-Cre) was infused into the VTA and a Cre-dependent virus expressing a neural activating DREADD (AAV-DIO-hM3D(Gq)-mCherry) was infused into the NTS (Fig 2A & 2B)

10.1007/s00213-015-4095-7 49 KumazawaY.ItagakiA.FukumotoM.FujisawaH.NishimuraC.NomotoK