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Compound 5 was isolated by silica gel column chromatography using a dichloromethane/methanol (DCM:MeOH = 20:1, V/V) eluent (yield: 61%)
[7] Both metformin and GLP-1RAs are known to improve leptin sensitivity, making the brain more responsive to the anorexigenic effects of the adipokine
Importantly, the expression level of the synaptic protein synaptophysin was much improved in the hippocampus and the neocortex, documenting that the synaptic loss that is common for this AD animal model has been reduced by liraglutide
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