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Microglia are in close communication with astrocytes to drive demyelination, as seen in EAE 13 , through secretion of pro-inflammatory cytokines, complement signaling 47 , and semaphorin and ephrin signaling 173

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MetS patients NO levels also increased with metformin (97)

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Intracellular glutathione also followed the trend of GCLC, exhibiting an NFT-dependent increase that was reversed by anti Nrf2-siRNA to levels comparable to those observed in untreated HepG2 cells (Fig