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Sermorelin is a 29-amino-acid fragment of native GHRH that was FDA-approved under the brand name Geref for pediatric growth-hormone deficiency before being voluntarily withdrawn from the U.S

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Conclusions Our findings reveal that L1-ATP8B1 plays a critical role in mitochondrial dysfunction and LUSC aggressiveness, suggesting it may serve as a promising prognostic biomarker and a novel therapeutic target for improving clinical outcomes in LUSC patients