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doi:10.1007/s00125-012-2776-x Muscelli E, Mari A, Casolaro A et al (2008) Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients

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Studies have shown that local COX-2 overexpression increases the number of CD90 + mouse skeletal stem cells (mSSCs) at the fracture site and targets CD90 + mSSCs to enhance canonical Wnt signal transduction, which results in the promotion of intramembranous osteogenesis and inhibition of intrachondral osteogenesis