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Abstract Osteoarthritis is a worldwide prevalent disease that imposes a significant socioeconomic burden on individuals and healthcare systems

Further in vitro studies have shown that IAA can promote epithelial cell proliferation and enhance tight junction repair by activating the AhR/IL-22 signaling pathway, thereby counteracting LPS-induced epithelial injury and preventing LPS-driven systemic inflammation 168

Dysregulation of GSH synthesis was associated with many diseases, such as diabetes mellitus, cholestatic liver disease, endotoxemia, alcoholic liver disease, cancer, and neurodegenerative diseases

The compositions of the prepared anionic (AL) and cationic (CL) formulations are shown in Table 1