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In a second cohort that was given polyclonal IgG from vaccinated macaques or control animals, loss of TGF- and increased IL-6 production by activated pulmonary macrophages was observed in macaques that were pre-treated with anti-S IgG, and lung pathology was described as skewed towards immunopathological inflammation

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Experimental work has shown that cagrilintide lowers body weight through brain amylin receptors, especially receptor systems involved in central appetite regulation [3]

120 , e517e524 (2018)