retatrutide phase 2 trial obesity just delivered one of the largest weight-loss signals we've ever seen in a medication trial. In a study: • Up to 24.2% mean weight loss at 48 weeks ESC 2024: Retatrutide improves lipid

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GIP receptors sit on fat cells and in the liver, providing additional metabolic signaling: Enhanced adipocyte metabolism fat cells respond better to signals telling them to release or burn fat Improved nutrient partitioning dietary fat gets directed toward oxidation rather than storage Greater weight loss tirzepatide produces about 50% more weight loss than semaglutide at comparable doses This translates to stronger lipid effects: about 20-30% triglyceride reduction in major obesity trials, and a large liver-fat signal in MRI studies

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