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The Phase 2 trial enrolled participants with obesity and evaluated multiple dose levels over 48 weeks: 1 mg dose: 8.7% average body weight reduction 4 mg dose (escalated from 2 mg): 17.1% average body weight reduction 8 mg dose (escalated from 2 mg): 22.8% average body weight reduction 12 mg dose (escalated from 2 mg): 24.2% average body weight reduction Placebo: 2.1% average body weight reduction Those Phase 2 numbers were striking enough

A recent study published in Ophthalmology Retina evaluated the relative risk associated with initiating GLP-1 agonist pharmacotherapy with these drug options on developing sight-threatening DR in routine clinical practice for patients with type 2 diabetes at moderate cardiovascular risk, which was defined as an annualized 1% to 5% predicted risk of experiencing a major adverse cardiovascular event

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