Indications: Overactive bladder Common symptoms include urgency, urinary incontinence, and increased urinary frequency Side Effects: urinary retention pruritus, rash constipation Pharmacokinetics: taken orally by tablet, 75 mg once daily hepatic metabolism predominantly by CYP3A4 vibegron does not inhibit CYP2D6 (unlike mirabegron), so its pattern of drug interactions differs from mirabegron vibegron is a P-gp substrate half life ~31 hours Drug Interactions: increases digoxin Cmax (21%) and AUC (11%) Notes: Vibegron is a newly approved drug, and the estimated Walmart cost for Gemtesa oral 75mg tablets is ~$485 for a supply of 30 tablets (GoodRx.com
doi:10.1046/j.1524-475X.1994.20406.x 9
If your post-meal drowsiness is persistent, worsens over time, or comes with other symptoms like unexplained weight changes, headaches, or concentration problems, its worth discussing with a healthcare professional
In more severe cases, a Vitamin-B deficiency can result in nerve damage, anemia and stomach complications
Pont A, Williams PL, Loose DS, et al
