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Attacha S, Solbach D, Bela K, Moseler A, Wagner S, Schwarzlnder M, Aller I, Muller SJ, Meyer AJ (2017) Glutathione peroxidase-like enzymes cover five distinct cell compartments and membrane surfaces in Arabidopsis thaliana
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Based on basic MichaelisMenten enzyme kinetics, by supplying the extra substrate and cofactor (i.e., folate and riboflavin) the reduced affinity can be overcome and the consequences of having the variant can be alleviated, e.g., reduction in elevated homocysteine, reduction in blood pressure, etc. This is the very definition of personalized nutrition, in this case an increased requirement of two essential nutrients based on a common genetic difference
Response: We appreciate the commenters for seeking clarification on the reason for including Maryland providers in ASM