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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

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Clinical Features The key facts to ascertain from a patient presenting with melena are: Colour and texture of the stool best described as a jet black, tar-like, and sticky Associated symptoms including any haematemesis, abdominal pain, weight loss, dyspepsia, or dysphagia Past medical history including smoking and alcohol status Drug history use of steroids, NSAIDs, anticoagulants, or iron tablets* A digital rectal examination is essential to confirm the melena

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Regarding lifestyle and behavioral modification, dietitians spoke about the need to motivate patients to make these changes and the importance of integrating diet improvements and exercise with medication