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MYELOPEROXIDASE (MPO) MPO released from activated neutrophils (and to a lesser extent from monocytes/macrophages) can accumulate in the subintimal space of the artery wall(272), so neutrophil activation indirectly increases the chance for lipoprotein oxidation

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AS is a chronic (lifelong) disease

Research should be limited to in vitro studies and approved preclinical laboratory models

Gastrointestinal side effects (nausea, vomiting) may exacerbate dehydration and prerenal acute kidney injury in susceptible patients, requiring hydration counseling