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Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets
Research has focused on its potential involvement in supporting redox balance protecting cells from oxidative stress and participating in various metabolic pathways
10.1074/jbc.270.20.11761 9 Brigelius-FlohR.MaiorinoM
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Herein, we demonstrate that single particle cryo-EM can be applied to a member of the pyridine nucleotide-disulfide oxidoreductase protein family, which includes crucial drug targets for several human diseases
Due to the strong product inhibition in the GSH biosynthetic pathway, high levels of intracellular content, yield and productivity of GSH are difficult to achieve
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