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Additionally, these drugs suppress glucagon secretion (a hormone that raises blood glucose), slow gastric emptying to reduce post-meal glucose spikes, and act on appetite centres in the brain to promote satiety and reduce food intake

2020 Aug;69(8):144151

Serotonin is capable of reducing ileal inflammation in mice by inducing acetylcholine release from myenteric plexus neurons, which bind to acetylcholine receptors on macrophages to reduce infiltration [301]

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Additionally, alcohol can worsen gastrointestinal side effects like nausea