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25 As an endocrine hormone, GLP-1 is secreted by enteroendocrine L-cells in the distal jejunum, ileum, and colon in response to food intake and neuroendocrine signals

The most common side effects include nausea, which affects roughly 20 to 44% of users depending on the study

Regulating insulin secretion by increasing insulin secretion from the pancreas in a glucose-dependent manner and increasing insulin-sensitivity in both alpha and beta cells Regulating glucagon secretion by decreasing glucagon secretion from the pancreas by engagement of a specific G protein-coupled receptor

Therefore, our study indicated that GLP-1-derived peptides offer effective pain relief without these significant adverse effects, suggesting their potential as safer alternatives for chronic pain management