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Recently, several pieces of evidence have expanded our understanding of the effects of GLP-1, demonstrating innovative actions even in well-known targets such as the pancreatic islet

Landmark trials show semaglutide (Wegovy) produces 10-15% body weight reduction over 68 weeks, while tirzepatide achieves 20-22% reduction by targeting dual GLP-1 and GIP pathways

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Research shows that a notable proportion of weight lost during GLP-1 treatment can come from lean body mass rather than fat alone - depending on the medication, individual factors, and whether resistance training was maintained during treatment

Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem