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Finally, the global economic rationale for obesity management is stronger than ever

Cell Death Differ 28 , 31993213 (2021)

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9 , 80 Central GLP1R activation also suppresses TLRdriven cytokine induction (e.g., TNF) via neuronal GLP1Rs, indicating a direct central mechanism beyond peripheral metabolic effects

Specifically, beyond the enteroendocrine L-cells of the intestine, GLP-1 is also produced as a neuropeptide by the pre-proglucagon neurons in the brain stem 3