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3 This shared endpoint is precisely why the class produces a recognizable common profile: dose-dependent reductions in HbA1c and body weight, a gastrointestinal side-effect signature dominated by nausea and altered bowel habit (a predictable consequence of slowed gastric emptying and central effects), and a glucose-dependent insulinotropic action that carries a low intrinsic risk of hypoglycemia when used as monotherapy

10.1007/s00401-019-02067-z 8 BrockschmidtA.TrostD.PeterzielH.ZimmermannK.EhrlerM.GrassmannH.et al (2012)

Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing IB kinase-dependent NF-B activation