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The precise mechanism of action by which SGLT2 inhibitors act at this level remains to be defined, but it does not seem to depend entirely on weight loss.30,37 Unlike the myocardium, SGLT2 receptor expression has been found in adipose tissue samples from patients undergoing cardiac surgery.38 In these same clinical samples, dapagliflozin was found to induce higher glucose uptake, lower expression of inflammatory cytokines, and better differentiation of epicardial adipocytes
According to the study from last July, which looked at the medical records of 16,800 Boston-area patients, 200 people with diabetes took semaglutide, and 17 of those suffered NAIONfour times the rate of those who didn't take the drug
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