By targeting two receptors, it produced an average weight loss of approximately 22.5% in clinical trials, which is significantly greater than the roughly 15% typically seen with semaglutide
Monlunabant is an investigational inverse agonist of the CB1 receptor which plays an important role in metabolism and appetite regulation in the central nervous system as well as in peripheral tissues such as adipose tissues, the gastrointestinal tract, kidneys, liver, pancreas, muscles and lungs
Potential additional beneficial effects of these drugs on bone are depicted GLP-1 GLP-1 plays a key role in maintaining glucose homeostasis by enhancing glucose-dependent insulin secretion from pancreatic beta-cells, 7 as well as inhibiting glucagon secretion and suppressing appetite
But the goal isnt simply appetite suppression
The injectable GLP-1 medications currently on the market have published higher average weight loss figures in their landmark trials: Semaglutide (Wegovy): Demonstrated approximately 14.9% average body weight reduction in the STEP 1 trial