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Weeks 1-4 Starting dose to assess tolerance Weeks 5-8 First dose increase Weeks 9-12 Therapeutic effects begin Weeks 13-16 Approaching target dose Week 17+ Full maintenance dose Side Effects & Safety Most gastrointestinal side effects are mild, temporary, and occur during the dose escalation period

img4 In this article, we review the important highlights from several key clinical studies evaluating CV and renal outcomes with GLP-1 RAs and SGLT-2 inhibitors, which led to their current place in therapy as options with proven benefits in patients both with and without diabetes

Often chosen for anti-aging and wellness benefits Considered safe for long term use, due to natural stimulation of GH

doi:10.1095/biolreprod.115.130658