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Increased expression of TIPE1 in DKD leads to the ubiquitinated degradation of PHB2, which disturbs mitochondrial homeostasis, inhibits PINK1/Parkin-mediated mitochondrial autophagy, and encourages EMT and kidney damage

Management includes eating smaller meals, avoiding trigger foods, remaining upright after eating, and using antacids or proton pump inhibitors if needed

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Diabetes Care 22 , C54C56 (1999)

7B, KEGG pathways on level 2, including metabolism of cofactors and vitamins, energy metabolism, glycan biosynthesis and metabolism, transcription, cellular processes and signaling, enzyme families, immune system, metabolism, genetic information processing, and biosynthesis of other secondary metabolites were lowered in XYP group as compared to MOD group