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The pathognostic Lewy bodies and Lewy neurites are composed mainly of abnormal cytoskeletal neurofilament proteins

Some healthcare providers may choose to implement a stepwise dose reduction (for example, decreasing from 15 mg to 10 mg to 5 mg over several weeks) not because tapering is pharmacologically required, but to allow time for: Transitioning to alternative therapies Implementing lifestyle modifications Monitoring metabolic parameters Adjusting other medications Psychological preparation for treatment changes This approach represents clinical judgment rather than medical necessity

Categorical variables were expressed in absolute frequencies and percentages, continuous parametric variables as mean and standard deviation (SD) and continuous non-parametric variables as median with inter-quartile range (IQR) or absolute range (AR) as appropriate

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Association between Semaglutide and Non-Arteritic Anterior Ischemic Optic Neuropathy: A Multinational Population-Based Real-World Study