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Rare conditions like autoimmune lymphoproliferative syndrome (ALPS) have been linked to these changes, although overall evidence is limited 9

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First, phase II clinical trials evaluating MOTS-c in type 2 diabetes and sarcopenia are in development, and their results will provide the first randomized controlled evidence in humans to define therapeutic doses with statistical rigor

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Over the last five years, GLP-1 receptor agonists semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) ignited the modern peptide craze by demonstrating dramatic efficacy for diabetes and obesity