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Reviewing diet, exercise, sleep, and stress management frequently identifies addressable factors that dose increases cannot overcome

Anti-obesity medications have the potential to become a $500bn market, the largest pharmaceutical market on the planet

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Drug Chem Toxicol

After 1 h, a sub-convulsive dose of picrotoxin (1 mg/kg) were injected intraperitoneally to mice and the behavioural parameters were evaluated for each mouse for a period of 30 min (Figure 1)