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174 In a trial on 48 overweight or obese participants, 1,000 mg pomegranate extract daily improved total cholesterol, LDL cholesterol, and HDL cholesterol levels as well as several other markers of metabolic health and inflammation

More recently, lorcaserin (Belviq), a 5-hydroxytryptamine receptor agonist that functioned as an appetite suppressant 12 , was approved in 2012 but was withdrawn in 2020, due to the increased risk of cancer based on emergent clinical data 13

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