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Chronic cocaine exposure has been linked to an increased risk of Parkinsons disease, as it promotes -synuclein overexpression in dopamine neurons, causing resting tremors and neurotoxic damage (Mash et al., 2003)

A lower fat diet may be better tolerated for people experiencing gut-related side effects like bloating, heart burn or diarrhoea

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While a substitution with the polar serine at position 13 retained wild-type dehydratase activity, presumably due to the alcohols ability to assume cysteines function in stabilizing deprotonated GS , the only other Pt GSTF8 variants to keep analbeit reducedflavan-3,3,4-triol ( 4 ) dehydration activity contained a glycine, alanine or asparagine mutation (Fig