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During the trial, additional anti-diabetic medication was initiated as an add on to randomized treatment by 10% and 4.3% of patients randomized to placebo and semaglutide tablets 14 mg, respectively

Lancet 359(9309):824830 Zhang T, Perkins MH, Chang H, Han W, de Araujo IE (2022) An inter-organ neural circuit for appetite suppression

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To effectively develop a PBPK model for studying mechanism-of-action-mediated DDIs, it is essential to carefully assess the extent to which these mechanisms impact pharmacokinetics

Assuming the remaining TRIUMPH trials (especially TRIUMPH-2 for diabetes) produce positive results and no unexpected safety signals emerge, FDA approval in late 2027 is the most probable outcome