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Moreover, the inhibition of TMA lyase with DMB was found to alleviate neuroinflammation, reduce A peptide formation (due to decreased secretase activity), and hence ameliorated the cognitive deterioration in mice ( 3.8 Trimethylamine-N-oxide and cancer The intestinal bacteria contribute to the oncogenesis and progression of several human cancers via inflammatory and metabolic mechanisms (Zitvogel et al., 2015)