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Given the sex differences detected in preclinical models of GLP-1 and the analogs action on motivated behavior described earlier and very well-established sex differences in various aspects of substance use, as well as well-established sex differences in presentation and prevalence of some neurodegenerative disorders, it is not unlikely that considerable sex differences also exist in endogenous or exogenous effects of GLP-1R receptor activation in both domains

The goal is finding the minimum effective dose that shifts your sleep architecture without overwhelming the delicate receptor systems involved

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