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Methylation of arginine residues by protein arginine methyltransferases (PRMTs) has been investigated in cancer cells and immune cells

10.1016/j.ejphar.2020.173810 145 PanX.WangP.LuoJ.WangZ.SongY.YeJ.et al (2015)

It can, especially if you are using chemotherapy, other injectable medicines, or high-dose antioxidant supplements

It acts as a primary defense system, neutralizing free radicalsunstable atoms that can damage cellsand supporting the livers ability to process and remove toxins

This was within the margin of clinical significance, meaning that the authors couldn't conclude that creatine increased the occurrence of heart palpitations