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For mild localized irritation, an over-the-counter hydrocortisone cream (0.5% to 1%) may help

Naltrexone -Naltrexone is commonly used to treat alcohol and opioid dependence

For patients living with dysautonomia, particularly postural orthostatic tachycardia syndrome (POTS), insulin resistance is not just a background metabolic issue

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However, even though the recommendations clearly state that liposuction should only be used in the context of research, NICE guidelines are only advisory and various types of liposuction for lipoedema are still available in the UK