For patients without neurological involvement , hydroxocobalamin 1 mg is administered intramuscularly three times a week for 2 weeks, followed by maintenance injections every three months for life (if due to pernicious anaemia or other non-dietary cause)
RMT is restricted to regions of high receptor density such as the microvascular endothelium of the cerebral cortex and basal ganglia
Neural tube defects: recent advances, unsolved questions, and controversies
Injectable use raises different sterility, dosing, safety, and regulatory concerns than topical use
J Neurochem 86:228237 Gegg ME, Clark JB, Heales SJR (2005) Co-culture of neurones with glutathione deficient astrocytes leads to increased neuronal susceptibility to nitric oxide and increased glutamate-cysteine ligase activity