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The greatest proteomic change was observed for TCR-T cells, which strongly upregulated many known markers of T cell activation upon coculture with tumor cells

While radiation-induced toxicity is a major concern during nuclear accidents, the same is desirable for achieving tumor control during radiotherapy [37, 39]

These findings indicate that FOXO4-DRI effectively promotes apoptosis in senescent cells

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The five most upregulated genes in microglia/macrophages were HSPH1, HSPB1, HSP90AA1, CHORDC1 and PTGES3, while the five most downregulated genes were CD14, SLC2A3, CCDC26, HAMP and TMEM163 (Fig