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Efficacy and safety of a novel dual GIP and GLP1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS1): a doubleblind, randomised, phase 3 trial

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Knee pain scores dropped 75.8% using the WOMAC pain assessment scale, with 14.1% of patients on the 9mg dose becoming completely pain-free compared to 4.2% on placebo

Gene expression patterns consistently show a shift from diseased states toward healthier configurations