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Vitamin B12 is mostly stored in the liver and thus its deficiency can lead to an increased risk of liver disease and inflammation which is referred to as cirrhosis

Compound 1 (6 g, 10.53 mmol) was dissolved in 50 mL MeOH with NaOH (2 g, 50 mmol) under ice bath conditions

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Understanding those differences makes the choice much simpler

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