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Decreased vitamin B12 absorption due to altered gut microbiota Potential for megaloblastic anemia in prolonged use Increased risk of neuropathy and other neurological complications Dose and Duration Considerations The risk of B12 deficiency with metformin depends on the dose and how long you take it

They also must meet the programs prior authorization criteria

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However, they can be unpleasant for some patients, affecting their ability to tolerate and adhere to the therapy