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Risk of bias (quality) assessment Two authors (AJ and SS-B) independently assessed the risk of bias of the trials according to version 2.0 of the Cochrane tool for risk of bias assessment (Reference Higgins, Thomas and Chandler13)

The results demonstrated that aspirin exerted an antitumor effect even under hypoxic conditions in PIK3CA -MT colorectal cancer cells and that its combination with drugs that reduced intracellular glutamine levels enhanced its antitumor effects

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Any additional information required to reanalyze the data reported in this paper is available from the corresponding author upon request