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10.1007/s11357-006-9027-3 [DOI] [PMC free article] [PubMed] [Google Scholar] deToledo-Morrell L, Geinisman Y, Morrell F (1988) Age-dependent alterations in hippocampal synaptic plasticity: relation to memory disorders

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Conservative management approaches include: Gradual activity modification : Patients who have recently lost significant weight may benefit from progressively increasing physical activity rather than abruptly intensifying exercise routines

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The higher the dosage, the more significant the weight loss tends to be, but even at lower doses, people are seeing transformative results