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Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species

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These vesicles can also increase the mRNA and protein expression of SMAD2, SMAD3, and SMAD5 both in vivo and in vitro , thereby promoting the proliferation of granulosa cells and inhibiting their apoptosis, improving ovarian function in mice with ovarian insufficiency

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doi: 10.1186/s13063-023-07466-y Summary Keywords inflammation, insulin resistance, micronutrients, oxidative stress, polycystic ovary syndrome, precision nutrition Citation Natarajan M, E