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Retatrutide (research grade), also designated LY3437943, is a long-acting synthetic peptide engineered to co-engage three distinct G-protein-coupled receptors: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)

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This raises the key question: why are so many people giving up on the drug