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On semaglutide, the starting dose of 0.25 mg is primarily for GI tolerance, significant appetite effects typically emerge at 1.0 mg and above

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When GLP-1 is secreted from L-cells through the TGR5 agonist, it stimulates GLP-1R in enterochromaffin cells and induces serotonin or 5-hydroxytryptamine (5-HT) secretion from these cells