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Contraindications, interactions and adverse effects: Systematic data on contraindications, drugdrug interactions, pregnancy/lactation safety, and a full adverseevent profile in humans are not available from randomized clinical trials

Indoleacrylic acid produced by commensal Peptostreptococcus species suppresses inflammation

It all comes down to the research question you're asking

That alone makes it biologically interesting, but its signaling effects are what make it valuable

Epigenetic regulation: Beyond immediate gene expression, some peptides create lasting epigenetic changes (DNA methylation, histone modifications)