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B12 & Autoimmune Disorders

The Increlex label and related mitigation literature describe pairing dosing with 30-50 grams of fast-acting carbohydrates within 30 minutes, avoiding fasted or pre-sleep dosing, and maintaining access to glucose tablets during research cycles

These include: Tingling, numbness, or a 'pins and needles' sensation in the hands and feet Difficulty with balance and coordination Muscle weakness Memory problems, difficulty concentrating, or 'brain fog' Mood changes, including low mood or irritability Important: New or worsening neurological symptoms such as paraesthesia, gait disturbance, or cognitive change should be treated as urgent

NAD+ itself doesn't absorb well orally because of its molecular weight, which explains why most supplements contain precursors like nicotinamide riboside

[Epub ahead of print] [PubMed: 40847076] Bailey CJ, Flatt PR, Conlon JM