It is proposed that the C* domain located at the C-terminus of CesAand the TE domain located at the C-terminus of CesB works as a cooperative esterification and depsipeptide elongation center, repeatedly recruiting the action of the C* domain to oligomerize tetradepsipeptides to give octa- and dodecadepsipeptides prior to macrocyclization by the TE domain
It is not designed to be kept as a refrigerated multi-dose stock, and a research vial reconstituted with bacteriostatic water is not the same preparation the labels stability data describe
[Abstract]2019 Nov;39(11):2303-2319
Serious Side Effects: More severe, though less common, adverse events include acute pancreatitis (inflammation of the pancreas), gallbladder issues (including gallstones), kidney problems (especially in cases of severe dehydration from gastrointestinal issues), and vision changes, particularly in individuals with diabetic retinopathy
2018 Mar 28;65(3):317-323