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That is one of the most overlooked challenges of GLP-1 therapy

Understanding the Whole Patient Patients using GLP-1 therapies often have obesity, diabetes, cardiovascular disease, and other chronic inflammatory conditions, reinforcing the importance of a whole-patient approach to care

In the databases of adverse drug events in multiple countries, the number of reports of mood changes, suicidal ideation and depression related to GLP-1RA has been on the rise, prompting regulatory authorities to request further monitoring [13, 15, 26, 27]

Anatomically, nasal mucosa is directly connected to the cerebrospinal fluid (CSF) and parenchymal regions of the brain (Dhuria et al., 2010