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SIRT4 represses peroxisome proliferator-activated receptor activity to suppress hepatic fat oxidation

To do this, he is looking into methods to increase the ability of the brain to neutralise ROS, such as boosting levels of the ROS scavenger glutathione

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Berberine supplementation did not cause changes in kidney or liver function tests in patients

CaMKK2 dysfunction may play an underlying role in this phenomenon as genetic deletion of Camkk2 in hippocampal neurons, myeloid cells and immortalized cell lines (HEK293 and HepG2) results in mitochondrial dysfunction that causes a similar switch in cellular energy generation from oxidative phosphorylation to glycolysis [43, 201, 202]