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In this sense, several authors have already reported a positive influence of DPP-4 inhibitors and GLP-1 on pancreatic tissue in the T2DM model, either by proliferation/maintenance of functional beta cells, inhibition of apoptosis or pancreatic islet neogenesis 9,45

The treatment involved intravenous DSIP administration on five consecutive days, followed by five injections every 48-72 hours